Whipple's disease is a rare infectious disease that can be fatal if left untreated. The disease is caused by infection with Tropheryma whipplei, a bacterium that may be more common than was initially assumed. Most patients present with nonspecific symptoms, and as routine cultivation of the bacterium is not feasible, it is difficult to diagnose this infection. On the other hand, due to the generic symptoms, infection with this bacterium is actually quite often in the differential diagnosis. The gold standard for diagnosis used to be periodic acid-Schiff (PAS) staining of duodenal biopsy specimens, but PAS staining has a poor specificity and sensitivity. The development of molecular techniques has resulted in more convenient methods for detecting T. whipplei infections, and this has greatly improved the diagnosis of this often missed infection. In addition, the molecular detection of T. whipplei has resulted in an increase in knowledge about its pathogenicity, and this review gives an overview of the new insights in epidemiology, pathogenesis, clinical manifestations, diagnosis, and treatment of Tropheryma whipplei infections.

中文翻译：

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惠氏周围性营养不良的临床表现，治疗和诊断。

Whipple病是一种罕见的传染病，如果不及时治疗，可能会致命。该疾病是由于感染了特发性鞭毛体（Tropheryma whipplei）引起的，这种细菌可能比最初设想的更为普遍。大多数患者表现出非特异性症状，并且由于常规培养细菌是不可行的，因此难以诊断这种感染。另一方面，由于一般症状，在鉴别诊断中实际上经常感染这种细菌。诊断的金标准曾经是十二指肠活检标本的高碘酸-希夫（PAS）染色，但PAS染色的特异性和敏感性较差。分子技术的发展导致了更方便的方法来检测T.whipplei感染，这大大改善了对这种经常漏诊的感染的诊断。