Introduction: The increasing prevalence of hyperglycaemia implicates a state of oxidative stress and inflammation. Traditional and emerging biomarkers associated with increasing hyperglycaemia were assessed to clarify their role they play in hyperglycaemia.

Results: 309 participants attending a rural diabetic screening program were categorised into control and quintile groups based upon glucose levels: 1st quintile - <4.5 mmol/L and 4th, 5th quintile - >6.1 mmol/L. Significant results were obtained for anthropometric data and biochemical markers - glucose, HbA1c and total cholesterol (P < 0.001); oxidative stress: glutathione (P < 0.001), glutathione:glutathione disulfide and 8-hydroxy-2-deoxyguanosine (P < 0.05). Interleukin -1β and inflammatory marker ratios IL-6/IL-10, IL-1β/IL-10, MCP-1/IL-10, IGF-1/IL-10 and IL-6/IL-1β were significant (P < 0.05).

Conclusion: This study provided further evidence that inflammatory and oxidative stress biomarkers may contribute to diagnostic information associated with preclinical increases in BGL. Further we have provided a unique study in the analysis of ratios of inflammatory biomarkers and correlations with increasing BGL.

简介：高血糖患病率的增加与氧化应激和炎症状态有关。对与高血糖升高相关的传统和新兴生物标志物进行了评估，以阐明它们在高血糖中发挥的作用。

结果：参加农村糖尿病筛查计划的 309 名参与者根据血糖水平分为对照组和五分位数组：第一五分位数 - <4.5 mmol/L，第四、第五五分位数 - >6.1 mmol/L。人体测量数据和生化标志物——葡萄糖、HbA1c 和总胆固醇（ P < 0.001）获得了显着结果；氧化应激：谷胱甘肽 ( P < 0.001)、谷胱甘肽：谷胱甘肽二硫化物和 8-羟基-2-脱氧鸟苷 ( P < 0.05)。白细胞介素-1β与炎症标志物比值IL-6/IL-10、IL-1β/IL-10、MCP-1/IL-10、IGF-1/IL-10和IL-6/IL-1β差异显着( P < 0.05)。

结论：这项研究提供了进一步的证据，表明炎症和氧化应激生物标志物可能有助于提供与 BGL 临床前增加相关的诊断信息。此外，我们还提供了一项独特的研究来分析炎症生物标志物的比率以及与 BGL 增加的相关性。