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Proximity to a Major Road and Plasma Cytokines in School-Aged Children.
Pediatric Allergy, Immunology, and Pulmonology ( IF 0.9 ) Pub Date : 2016-09-01 , DOI: 10.1089/ped.2016.0649
Franziska Rosser 1 , Erick Forno 1 , John Brehm 1 , Yueh-Ying Han 1 , Nadia Boutaoui 1 , Angel Colón-Semidey 2 , María Alvarez 2 , Edna Acosta-Pérez 2 , Kristen S Kurland 3 , John F Alcorn 1 , Glorisa Canino 2 , Juan C Celedón 1
Affiliation  

Traffic-related air pollution (TRAP) may affect immune responses, including those in the TH2 and TH17 pathways. To examine whether TRAP is associated with plasma level of TH17-, TH1-, and TH2-related cytokines in children with and without asthma, a cross-sectional study of 577 children (ages 6-14 years) with (n = 294) and without (n = 283) asthma in San Juan (Puerto Rico) was performed. Residential distance to a major road was estimated using geocoded home addresses for study participants. A panel of 14 cytokines, enriched for the TH17 pathway, was measured in plasma. Asthma was defined as physician-diagnosed asthma and current wheeze. Multivariable linear regression was used to examine the association of residential distance to a major road (a marker of TRAP), asthma, and cytokine levels. Among all participating children, residential proximity to a major road was significantly associated with increased plasma level of IL-31, even after adjustment for relevant covariates and correction for multiple testing. The presence of asthma modified the estimated effect of the residential distance to a major road on plasma TNF-α (P for interaction = 0.00047). Although living farther from a major road was significantly associated with lower TNF-α level in control subjects, no such decrease was seen in children with asthma. In a direct comparison of cases and control subjects, children with asthma had significantly higher levels of IL-1β, IL-22, and IL-33 than control subjects. TRAP is associated with increased levels of proinflammatory cytokines among Puerto Rican children, who belong to an ethnic group with high risk for asthma.

中文翻译:

学龄儿童靠近主要道路和血浆细胞因子的情况。

与交通有关的空气污染(TRAP)可能会影响免疫反应,包括TH2和TH17途径中的那些反应。为了研究TRAP是否与哮喘患儿和非哮喘患儿血浆TH17,TH1和TH2相关的细胞因子相关,对577名(n = 294)儿童(6-14岁)的横断面研究进行了研究。在圣胡安(波多黎各)进行了无(n = 283)哮喘治疗。研究对象使用地理编码的家庭住址估算了到主要道路的居住距离。在血浆中测量了一组丰富的TH17途径的14种细胞因子。哮喘被定义为医生诊断的哮喘和当前的喘息。多变量线性回归用于检查居住距离与主要道路(TRAP的标志),哮喘和细胞因子水平之间的关系。在所有参与的儿童中,即使在调整了相关协变量并进行了多次测试校正之后,住宅靠近主要道路的情况也与IL-31血浆水平的升高显着相关。哮喘的存在改变了距主要道路的居住距离对血浆TNF-α的估计影响(相互作用P = 0.00047)。尽管离主要道路较远的生活与对照组受试者的TNF-α水平降低显着相关,但哮喘儿童未见这种下降。在病例与对照对象的直接比较中,哮喘患儿的IL-1β,IL-22和IL-33水平明显高于对照对象。TRAP与波多黎各儿童中促炎细胞因子水平升高相关,波多黎各儿童属于哮喘高危人群。
更新日期:2019-11-01
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