Recent advances in biomaterials design offer the potential to actively control immune cell activation and behaviour. Many human diseases, such as infections, cancer, and autoimmune disorders, are partly mediated by inappropriate or insufficient activation of the immune system. T cells play a central role in the host immune response to these diseases, and so constitute a promising cell type for manipulation. In vivo, T cells are stimulated by antigen presenting cells (APC), therefore to design immunoengineering biomaterials that control T cell behaviour, artificial interfaces that mimic the natural APC-T cell interaction are required. This review draws together research in the design and fabrication of such biomaterial interfaces, and highlights efforts to elucidate key parameters in T cell activation, such as substrate mechanical properties and spatial organization of receptors, illustrating how they can be manipulated by bioengineering approaches to alter T cell function.

中文翻译：

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采用先进生物材料的 T 细胞免疫工程。


生物材料设计的最新进展提供了主动控制免疫细胞激活和行为的潜力。许多人类疾病，例如感染、癌症和自身免疫性疾病，部分是由免疫系统激活不当或不足引起的。 T 细胞在宿主对这些疾病的免疫反应中发挥着核心作用，因此构成了一种有前途的操纵细胞类型。在体内，T 细胞受到抗原呈递细胞 (APC) 的刺激，因此要设计控制 T 细胞行为的免疫工程生物材料，需要模拟自然 APC-T 细胞相互作用的人工界面。这篇综述汇集了此类生物材料界面的设计和制造研究，并强调了阐明 T 细胞激活关键参数的努力，例如基质机械特性和受体的空间组织，说明如何通过生物工程方法操纵它们来改变 T细胞功能。