Two new somatostatin analogs with a characteristic part of the sequence -c(Cys-Phe-Trp-Lys-Thr-Cys)- and with two histidine and two aspartic acid moieties in their structures were synthesized and analyzed in terms of their coordination abilities with copper (II) ions. Both peptides bind Cu(II) effectively. Ligands form 4N complexes with \(\left\{ {{\text{N}}_{\text{Im}} ,{ 3} {\text{N}}_{\text{amide}}^{ - } } \right\}\) binding mode in a basic range of pH. But in spite of very similar sequences of the two peptides a significant difference in the effectiveness of the binding of copper (II) ions was observed.

中文翻译：

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生长抑素新环类似物的配位能力。

合成了两个新的生长抑素类似物，其结构的特征部分为-c（Cys-Phe-Trp-Lys-Thr-Cys）-，其结构中具有两个组氨酸和两个天冬氨酸部分，并根据它们的配位能力进行了分析。铜（II）离子。两种肽均有效结合Cu（II）。配体与\（\ left \ {{{\ text {N}} _ {\ text {Im}}，{3} {\ text {N}} _ {\ text {amide}} ^ {-}形成4N络合物} \ right \} \）在基本pH范围内的结合模式。但是，尽管两种肽的序列非常相似，但仍观察到铜（II）离子结合效果的显着差异。