A local effect model (LEM)-based framework capable of interpolating nanoparticle-enhanced photon-irradiated clonogenic cell survival fraction measurements as a function of nanoparticle concentration was developed and experimentally benchmarked for gold nanoparticle (AuNP)-doped bovine aortic endothelial cells (BAECs) under superficial kilovoltage X-ray irradiation. For three different superficial kilovoltage X-ray spectra, the BAEC survival fraction response was predicted for two different AuNP concentrations and compared to experimental data. The ability of the developed framework to predict the cell survival fraction trends is analysed and discussed. This developed framework is intended to fill in the existing gaps of individual cell line response as a function of NP concentration under photon irradiation and assist the scientific community in planning future pre-clinical trials of high Z nanoparticle-enhanced photon radiotherapy.

中文翻译：

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基于局部效应模型的插值框架，用于实验性纳米粒子放射增敏数据。

开发了一种基于局部效应模型（LEM）的框架，该框架能够内插纳米颗粒增强的光子辐照的成克隆细胞存活分数测量值（作为纳米颗粒浓度的函数），并为掺有金纳米颗粒（AuNP）的牛主动脉内皮细胞（BAEC）进行了基准测试在千伏电压下进行X射线辐照。对于三种不同的表面千伏X射线光谱，预测了两种不同AuNP浓度的BAEC存活分数响应，并将其与实验数据进行了比较。分析和讨论了已开发框架预测细胞存活分数趋势的能力。