Deregulated metabolism is a well-established hallmark of cancer. At the hub of various metabolic pathways deeply integrated within mitochondrial functions, the α-ketoglutarate dehydrogenase complex represents a major modulator of electron transport chain activity and tricarboxylic acid cycle (TCA) flux, and is a pivotal enzyme in the metabolic reprogramming following a cancer cell’s change in bioenergetic requirements. By contributing to the control of α-ketoglutarate levels, dynamics, and oxidation state, the α-ketoglutarate dehydrogenase is also essential in modulating the epigenetic landscape of cancer cells. In this review, we will discuss the manifold roles that this TCA enzyme and its substrate play in cancer.

中文翻译：

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癌症代谢可塑性中的α-酮戊二酸脱氢酶复合物

代谢失调是癌症的公认标志。α-酮戊二酸脱氢酶复合物是与线粒体功能紧密结合的各种代谢途径的枢纽，是电子传递链活性和三羧酸循环 (TCA) 通量的主要调节剂，是癌细胞发生代谢重编程的关键酶。生物能需求的变化。通过有助于控制 α-酮戊二酸水平、动力学和氧化态，α-酮戊二酸脱氢酶在调节癌细胞的表观遗传景观中也必不可少。在这篇综述中，我们将讨论这种 TCA 酶及其底物在癌症中的多种作用。