Cells of the immune system synthesize, store, and secrete polypeptide and amino acid type hormones, which also influence their functions, having receptors for different hormones. In the present experiment immunophenotyped immune cells isolated from bone marrow, thymus, and peritoneal fluid of mice were used for demonstrating the adrenocorticotropic hormone (ACTH) and triiodothyronine (T3) hormone production of differentiating immune cells. Both hormones were found in each cell type, and in each maturation state, which means that all cells are participating in the hormonal function of the immune system. The lineage-independent presence of ACTH and T3 in differentiating hematopoietic cells denotes that their expression ubiquitous during lymphocyte development. Higher ACTH and T3 content of B cells shows that these cells are the most hormonally active and suggests that the hormones may have an autocrine regulatory role in B cell development. Developing T cells showed heterogeneous hormone production which was associated with their maturation state. Differences in the hormone contents of immune cells isolated from different organs indicate that their hormone production is defined by their differentiation or maturation state, however, possibly also by the local microenvironment.

中文翻译：

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免疫表型淋巴细胞亚群的激素（ACTH，T3）含量。

免疫系统的细胞合成，储存和分泌多肽和氨基酸类型的激素，它们也影响它们的功能，并具有不同激素的受体。在本实验中，从小鼠的骨髓，胸腺和腹膜液中分离出的免疫表型免疫细胞被用于证明分化型免疫细胞的促肾上腺皮质激素（ACTH）和三碘甲腺嘌呤（T3）激素的产生。两种激素均在每种细胞类型和每种成熟状态下发现，这意味着所有细胞都参与免疫系统的激素功能。在分化的造血细胞中，ACTH和T3的谱系非依赖性存在表明它们的表达在淋巴细胞发育过程中无处不在。B细胞中较高的ACTH和T3含量表明，这些细胞具有最强的激素活性，表明该激素可能在B细胞发育中具有自分泌调节作用。发育中的T细胞显示出异质激素产生，这与它们的成熟状态有关。从不同器官中分离出来的免疫细胞的激素含量的差异表明，它们的激素产生是由它们的分化或成熟状态决定的，但是，也可能是由局部的微环境决定的。