Magnetic nanoparticles (MNPs) have been used in many diagnostic and therapeutic biomedical applications over the past few decades to enhance imaging contrast, steer drugs to targets, and treat tumors via hyperthermia. Optical coherence tomography (OCT) is an optical biomedical imaging modality that relies on the detection of backscattered light to generate high-resolution cross-sectional images of biological tissue. MNPs have been utilized as imaging contrast and perturbative mechanical agents in OCT in techniques called magnetomotive OCT (MM-OCT) and magnetomotive elastography (MM-OCE), respectively. MNPs have also been independently used for magnetic hyperthermia treatments, enabling therapeutic functions such as killing tumor cells. It is well known that the localized tissue heating during hyperthermia treatments result in a change in the biomechanical properties of the tissue. Therefore, we propose a novel dosimetric technique for hyperthermia treatment based on the viscoelasticity change detected by MM-OCE, further enabling the theranostic function of MNPs. In this paper, we first review the basic principles and applications of MM-OCT, MM-OCE, and magnetic hyperthermia, and present new preliminary results supporting the concept of MM-OCE-based hyperthermia dosimetry.

中文翻译：

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基于动态组织生物力学的磁热疗剂量学磁动光学相干弹性成像

在过去的几十年里，磁性纳米粒子 (MNP) 已被用于许多诊断和治疗生物医学应用中，以增强成像对比度、将药物导向目标并通过热疗治疗肿瘤。光学相干断层扫描 (OCT) 是一种光学生物医学成像模式，它依赖于检测反向散射光来生成生物组织的高分辨率横截面图像。MNP 已分别在称为磁动 OCT (MM-OCT) 和磁动弹性成像 (MM-OCE) 的技术中用作 OCT 中的成像对比度和微扰机械剂。MNPs 也被独立用于磁热疗，从而实现诸如杀死肿瘤细胞等治疗功能。众所周知，在热疗过程中局部组织加热会导致组织的生物力学特性发生变化。因此，我们提出了一种基于 MM-OCE 检测到的粘弹性变化的用于热疗的新型剂量学技术，进一步实现了 MNP 的治疗诊断功能。在本文中，我们首先回顾了 MM-OCT、MM-OCE 和磁热疗的基本原理和应用，并提出了支持基于 MM-OCE 的热疗剂量学概念的新的初步结果。