Intramammary infection (IMI) treatment and prevention at drying-off is one of the leading causes for using antimicrobials on dairy farms. The objective of the current paper is to describe the protocol used for conducting a systematic review of the literature on non-antibiotic strategies that can be used on dairy cows at dry off to treat and prevent IMI. Relevant literature will be identified using a combination of database search strategies and iterative screening of references. To be included in the review, articles will have to: (1) be published after 1969; (2) be written in English, French, or Spanish; (3) use a study design such as a controlled trial, an observational study, or an experimental study conducted in vivo; (4) be conducted on commercial dairy cows; (5) investigate a non-antibiotic intervention used at dry off; and finally, (6) report on a relevant mastitis outcome. Titles and abstracts, then full articles will be reviewed for inclusion. Specific data will be extracted and risk of bias will be assessed for all included articles. The planned systematic review will be the first to colligate, in a coherent whole, studies investigating non-antibiotic strategies for treating and preventing IMI at drying-off.

中文翻译：

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干燥治疗和预防乳房内感染的非​​抗生素方法：系统评价和荟萃分析方案

干燥时的乳房内感染 (IMI) 治疗和预防是在奶牛场使用抗菌剂的主要原因之一。本论文的目的是描述用于对非抗生素策略的文献进行系统评价的方案，这些策略可用于奶牛干涸以治疗和预防 IMI。将使用数据库搜索策略和参考文献的迭代筛选相结合来确定相关文献。要被纳入审查，文章必须：（1）在 1969 年之后发表；(2) 以英文、法文或西班牙文书写；(3) 使用研究设计，例如对照试验、观察性研究或进行的实验研究体内; (4) 对商品奶牛进行；(5) 调查干燥时使用的非抗生素干预措施；最后，(6) 报告相关的乳腺炎结果。标题和摘要，然后是完整的文章将被审查纳入。将提取特定数据并评估所有纳入文章的偏倚风险。计划中的系统评价将是第一个在一个连贯的整体中整合研究用于治疗和预防干燥时 IMI 的非抗生素策略的研究。