BACKGROUND The purpose of the study was to evaluate time trends and effects of co-existing autism spectrum disorders (ASD) on outcome in an ongoing long-term follow-up study of anorexia nervosa (AN). METHODS The Morgan-Russell Outcome Assessment Schedule (MROAS) was used at 6-, 10- and 18-year follow-up of a representative sample of 51 individuals with teenage-onset AN and a matched group of 51 healthy comparison cases. The full multinomial distribution of responses for the full scale and each of the subscales was evaluated using exact nonparametric statistical methods. The impact of diagnostic stability of ASD on outcome in AN was evaluated in a dose-response model. RESULTS There were no deaths in either group. Food intake and menstrual pattern were initially poor in the AN group but normalised over time. MROAS 'mental state' was much poorer in the AN group and did not improve over time. The psychosexual MROAS domains 'attitudes' and 'aims' showed persistent problems in the AN group. In the MROAS socioeconomic domain, the subscales 'personal contacts', 'social activities' and 'employment record' all showed highly significant between-group differences at all three follow-ups. A statistically significant negative dose-response relationship was found between a stable diagnosis of ASD over time and the results on the subscales 'mental state', 'psychosexual state' and 'socio-economic state'. CONCLUSIONS Outcome of teenage-onset AN is favourable with respect to mortality and persisting eating disorder, but serious problems remain in the domains 'mental state', 'psychosexual function' and 'socioeconomic state'. Outcome is considerably worse if ASD is present. Treatment programmes for AN need to be modified so as to accommodate co-existing ASD.

中文翻译：

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通过Morgan-Russell结果评估时间表评估自闭症谱系障碍对青少年发作性神经性厌食症结局的影响：一项基于社区的受控研究。

背景技术这项研究的目的是评估时间趋势以及并存的自闭症谱系障碍（ASD）对神经性厌食症（AN）进行的长期长期随访研究的结果。方法对51例青少年发病的AN患者和51例健康对照者的配对组进行了6、10和18年的随访，采用了Morgan-Russell结果评估表（MROAS）。使用精确的非参数统计方法评估了完整量表和每个子量表的响应的完整多项式分布。在剂量反应模型中评估了ASD诊断稳定性对AN结局的影响。结果两组均无死亡病例。最初，AN组的食物摄入量和月经方式较差，但随着时间的推移而恢复正常。MROAS的“精神状态” 在AN组中更差，并且随着时间的推移并没有改善。心理性MROAS领域的“态度”和“目标”在AN组中显示出持续存在的问题。在MROAS的社会经济领域中，在所有三个随访中，分量表“人际关系”，“社会活动”和“就业记录”均显示出非常显着的组间差异。在一段时间内稳定的ASD诊断与“精神状态”，“心理状态”和“社会经济状态”子量表的结果之间发现了统计学上显着的负剂量反应关系。结论青少年死亡率的结果在死亡率和持续饮食失调方面是有利的，但是在“精神状态”，“性功能”和“精神状态”方面仍然存在严重问题。社会经济状况”。如果存在ASD，结果会严重恶化。需要修改AN的治疗方案，以适应并存的ASD。