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Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment.
World Journal of Stem Cells ( IF 3.6 ) Pub Date : 2017-1-12 , DOI: 10.4252/wjsc.v8.i12.399
Antonin Bukovsky 1
Affiliation  

Blood mononuclear cells consist of T cells and monocyte derived cells. Beside immunity, the blood mononuclear cells belong to the complex tissue control system (TCS), where they exhibit morphostatic function by stimulating proliferation of tissue stem cells followed by cellular differentiation, that is stopped after attaining the proper functional stage, which differs among various tissue types. Therefore, the term immune and morphostatic system (IMS) should be implied. The TCS-mediated morphostasis also consists of vascular pericytes controlled by autonomic innervation, which is regulating the quantity of distinct tissues in vivo. Lack of proper differentiation of tissue cells by TCS causes either tissue underdevelopment, e.g., muscular dystrophy, or degenerative functional failures, e.g., type 1 diabetes and age-associated diseases. With the gradual IMS regression after 35 years of age the gonadal infertility develops, followed by a growing incidence of age-associated diseases and cancers. Without restoring an altered TCS function in a degenerative disease, the implantation of tissue-specific stem cells alone by regenerative medicine can not be successful. Transfused young blood could temporarily restore fertility to enable parenthood. The young blood could also temporarily alleviate aging diseases, and this can be extended by substances inducing IMS regeneration, like the honey bee propolis. The local and/or systemic use of honey bee propolis stopped hair and teeth loss, regressed varicose veins, improved altered hearing, and lowered high blood pressure and sugar levels. Complete regression of stage IV ovarian cancer with liver metastases after a simple elaborated immunotherapy is also reported.

中文翻译:

血液单核细胞参与不孕症、年龄相关疾病和癌症治疗。

血液单核细胞由 T 细胞和单核细胞衍生细胞组成。除了免疫之外,血液单核细胞属于复杂的组织控制系统(TCS),它们通过刺激组织干细胞增殖和随后的细胞分化来表现出形态稳定功能,在达到适当的功能阶段后停止,不同组织的功能阶段有所不同类型。因此,应该暗示术语免疫和形态稳定系统(IMS)。TCS 介导的形态发育还由受自主神经支配控制的血管周细胞组成,自主神经支配调节体内不同组织的数量。TCS缺乏对组织细胞的适当分化导致组织发育不良,例如肌营养不良,或退行性功能衰竭,例如1型糖尿病和与年龄相关的疾病。35 岁后,随着 IMS 逐渐消退,性腺不育症逐渐发展,随之而来的是与年龄相关的疾病和癌症的发病率不断增加。如果不能恢复退行性疾病中改变的 TCS 功能,仅通过再生医学植入组织特异性干细胞就不可能成功。输入年轻人的血液可以暂时恢复生育能力,从而成为父母。年轻的血液还可以暂时缓解衰老疾病,并且可以通过诱导 IMS 再生的物质(例如蜜蜂蜂胶)来延长这种效果。局部和/或全身使用蜂胶可以阻止头发和牙齿脱落,消除静脉曲张,改善听力改变,并降低高血压和血糖水平。还报道了经过简单的精细免疫治疗后,伴有肝转移的 IV 期卵巢癌完全消退。
更新日期:2020-08-21
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