The specificity of DNA hybridization allows for the modular design of 2D and 3D shapes with wide-ranging applications including sensors, actuators, and even logic devices. The inherent biocompatibility of DNA and the ability to produce monodisperse structures of controlled shape and size make DNA nanostructures of interest as potential drug and gene delivery vehicles. In this review, we discuss several new approaches for the assembly of DNA nanostructures, advances in the modeling of these structures, and we highlight recent studies on the use of DNA nanotechnology for therapeutic applications such as drug delivery in tumor models.

中文翻译：

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DNA纳米结构：从组装到应用的转变。

DNA杂交的特异性允许2D和3D形状的模块化设计以及包括传感器，执行器甚至逻辑设备在内的广泛应用。DNA固有的生物相容性以及产生形状和大小可控的单分散结构的能力使DNA纳米结构成为潜在的药物和基因传递载体。在这篇综述中，我们讨论了DNA纳米结构组装的几种新方法，这些结构的建模进展，并且我们重点介绍了将DNA纳米技术用于治疗应用（例如肿瘤模型中的药物递送）的最新研究。