The daily use by people of wireless communication devices has increased exponentially in the last decade, begetting concerns regarding its potential health hazards. Drosophila melanogaster four days-old adult female flies were exposed for 30 min to radiation emitted by a commercial mobile phone at a SAR of 0.15 W/kg and a SAE of 270 J/kg. ROS levels and apoptotic follicles were assayed in parallel with a genome-wide microarrays analysis. ROS cellular contents were found to increase by 1.6-fold (x), immediately after the end of exposure, in follicles of pre-choriogenic stages (germarium - stage 10), while sporadically generated apoptotic follicles (germarium 2b and stages 7–9) presented with an averaged 2x upregulation in their sub-population mass, 4 h after fly's irradiation with mobile device. Microarray analysis revealed 168 genes being differentially expressed, 2 h post-exposure, in response to radiofrequency (RF) electromagnetic field-radiation exposure (≥1.25x, P < 0.05) and associated with multiple and critical biological processes, such as basic metabolism and cellular subroutines related to stress response and apoptotic death. Exposure of adult flies to mobile-phone radiation for 30 min has an immediate impact on ROS production in animal's ovary, which seems to cause a global, systemic and non-targeted transcriptional reprogramming of gene expression, 2 h post-exposure, being finally followed by induction of apoptosis 4 h after the end of exposure. Conclusively, this unique type of pulsed radiation, mainly being derived from daily used mobile phones, seems capable of mobilizing critical cytopathic mechanisms, and altering fundamental genetic programs and networks in D. melanogaster.

在过去的十年中，人们对无线通信设备的日常使用呈指数增长，这引起了人们对其潜在的健康危害的担忧。果蝇将四天大的成年雌性蝇暴露于商用手机发出的SAR为0.15 W / kg和SAE为270 J / kg的辐射下30分钟。与全基因组微阵列分析平行地测定ROS水平和凋亡滤泡。暴露结束后，在成色前阶段（ger- 10期）的卵泡中，ROS细胞含量立即增加了1.6倍（x），而偶发产生的凋亡卵泡（ger2b和7-9期）中的ROS细胞含量增加了1.6倍（x）。在用移动设备照射苍蝇后4小时，他们的平均亚群质量平均出现了2倍的上调。微阵列分析显示，在暴露后2 h，对射频（RF）电磁场-辐射暴露有168个基因差异表达（≥1.25x，P <0.05）并与多种和关键的生物学过程相关，例如与应激反应和凋亡死亡相关的基本代谢和细胞子程序。成年果蝇暴露于手机辐射下30分钟会对动物卵巢中的ROS产生立即产生影响，这似乎会导致暴露后2 h对基因表达进行全局，系统和非靶向的转录重编程，最后进行追踪在暴露结束后4小时通过诱导凋亡。结论是，这种独特的脉冲辐射主要来自日常使用的手机，似乎能够动员关键的细胞病变机制，并改变黑腹果蝇的基本遗传程序和网络。