We report the use of high-resolution magnetic resonance imaging methods to observe pattern formation in colonies of Saccharomyces cerevisiae. Our results indicate substantial signal loss localized in specific regions of the colony rendering useful imaging contrast. This imaging contrast is recognizable as being due to discontinuities in magnetic susceptibility (χ) between different spatial regions. At the microscopic pixel level, the local variations in the magnetic susceptibility (Δχ) induce a loss in the NMR signal, which was quantified via T2 and T2* maps, permitting estimation of Δχ values for different regions of the colony. Interestingly the typical petal/wrinkling patterns present in the colony have a high degree of correlation with the estimated susceptibility distribution. We conclude that the presence of magnetic susceptibility inclusions, together with their spatial arrangement within the colony, may be a potential cause of the susceptibility distribution and therefore the contrast observed on the images.

中文翻译：

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通过磁共振成像在酿酒酵母酵母菌落中的模式。

我们报告使用高分辨率的磁共振成像方法来观察在酿酒酵母菌落的模式形成。我们的结果表明大量的信号损失集中在菌落的特定区域，从而提供了有用的成像对比度。由于不同空间区域之间的磁化率（χ）不连续，因此可以识别该成像对比度。在微观像素级别，磁化率（Δχ）的局部变化会引起NMR信号的损失，该损失可通过T2和T2 *图进行量化，从而可以估计菌落不同区域的Δχ值。有趣的是，菌落中典型的花瓣/皱纹与估计的药敏性分布具有高度的相关性。