Purpose

Inflammation with leukocytic infiltration, degradation of extracellular matrix (ECM), and depletion of vascular smooth muscle cells (VSMC) are pathological hallmarks of abdominal aortic aneurysm (AAA). The aim of this study was to further evaluate relationships betweenAAAand inflammatory biomarkers, interleukin- 6 (IL-6), tumour necrosis factor-α (TNF-α), endothelin-1 (ET-1) and soluble urokinase-type plasminogen activator receptor (suPAR), by comparing levels in 65-year-old men with and without AAA at ultrasound screening.We also evaluated whether any biomarker can independently predict AAA at screening, and clarified potential correlations between aortic diameter and blood levels of these biomarkers.

Results

There were significant (p ɤ 0.05) differences between subjects with and without AAA for the following variables: p-leukocyte count (TLC) (p<0.001), p-homocysteine (p<0.001), p-TNF-α (p = 0.023), p-IL-6 (p<0.001), p-ET-1 (p = 0.002), p-suPAR (p<0.001), ankle brachial index (ABI) (p<0.001), plasma (p)-creatinine (p = 0.049), p-total cholesterol (p<0.001), p-high density lipoprotein (HDL) (p<0.001) and low density lipoprotein (LDL) cholesterol (p = 0.001), smoking habits (p<0.001), and use of antihypertensive (p<0.001) and lipid-lowering (p = 0.001) drugs. When the above variables were stepwise excluded in a logistic regression model, only p-IL-6 (p = 0.002), p-homocysteine (p = 0.015), p-HDL (p = 0.004), ABI in the right (p = 0.005) and left (p = 0.094) leg, smoking habits (p = 0.003), and antihypertensive drug use (p = 0.045), differed between groups. Significant correlations with aortic diameter existed for p-TNF-α (p = 0.028), p-IL-6 (p<0.001), p-ET-1 (p = 0.002) and p-suPAR (p<0.001) in the entire study population, and for p-TNF-α (p = 0.023), p-ET-1 (p = 0.009) and p-suPAR (p = 0.001) among men with AAA.

Conclusions

Several inflammatory biomarkers were significantly elevated and correlated with aortic diameter among 65-year old men with AAA at ultrasound screening. IL-6, homocysteine and use of antihypertensive medication remained elevated in the logistic regression model, together with known risk markers for AAA such as smoking and signs of atherosclerosis.

中文翻译：

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与腹主动脉瘤相关的炎症标志物。

目的

白细胞浸润引起的炎症，细胞外基质（ECM）的降解以及血管平滑肌细胞的耗竭（VSMC）是腹主动脉瘤（AAA）的病理标志。这项研究的目的是进一步评估AAA与炎症生物标志物，白介素6（IL-6），肿瘤坏死因子α（TNF-α），内皮素1（ET-1）和可溶性尿激酶型纤溶酶原激活剂受体之间的关系。 （suPAR），通过比较超声筛查时65岁男性有和没有AAA的水平，我们还评估了是否有任何生物标志物可以在筛查时独立预测AAA，并阐明了这些生物标志物的主动脉直径与血液水平之间的潜在相关性。

结果

有以下变量的有和没有AAA的受试者之间存在显着差异（pɤ0.05）：p-白细胞计数（TLC）（p <0.001），p-同型半胱氨酸（p <0.001），p-TNF-α（p = 0.023），p-IL-6（p <0.001），p-ET-1（p = 0.002），p-suPAR（p <0.001），踝肱指数（ABI）（p <0.001），血浆（p） -肌酐（p = 0.049），p-总胆固醇（p <0.001），p-高密度脂蛋白（HDL）（p <0.001）和低密度脂蛋白（LDL）胆固醇（p = 0.001），吸烟习惯（p < 0.001），以及使用降压药（p <0.001）和降脂药（p = 0.001）。当在Logistic回归模型中逐步排除上述变量时，右侧只有p-IL-6（p = 0.002），p-高半胱氨酸（p = 0.015），p-HDL（p = 0.004），ABI（p = 0.005）和左腿（p = 0.094），吸烟习惯（p = 0.003）和使用降压药（p = 0。045），各组之间有所不同。p-TNF-α（p = 0.028），p-IL-6（p <0.001），p-ET-1（p = 0.002）和p-suPAR（p <0.001）与主动脉直径存在显着相关性。整个研究人群，AAA男性中的p-TNF-α（p = 0.023），p-ET-1（p = 0.009）和p-suPAR（p = 0.001）。

结论

在超声筛查中，在65岁AAA男性中，几种炎症生物标记物显着升高并与主动脉直径相关。在Logistic回归模型中，IL-6，高半胱氨酸和使用降压药的使用以及已知的AAA危险标志物（例如吸烟和动脉粥样硬化的征兆）一直保持较高水平。