PURPOSE Human beings frequently experience fear, phobia, migraine and hallucinations, however, the cerebral mechanisms underpinning these conditions remain poorly understood. Towards this goal, in this work, we aim to correlate the human ocular perceptions with visual hallucinations, and map them to their cerebral origins. METHODS An fMRI study was performed to examine the visual cortical areas including the striate, parastriate and peristriate cortex in the occipital lobe of the human brain. 24 healthy subjects were enrolled and four visual patterns including hallucination circle (HCC), hallucination fan (HCF), retinotopy circle (RTC) and retinotopy cross (RTX) were used towards registering their impact in the aforementioned visual related areas. One-way analysis of variance was used to evaluate the significance of difference between induced activations. Multinomial regression and and K-means were used to cluster activation patterns in visual areas of the brain. RESULTS Significant activations were observed in the visual cortex as a result of stimulus presentation. The responses induced by visual stimuli were resolved to Brodmann areas 17, 18 and 19. Activation data clustered into independent and mutually exclusive clusters with HCC registering higher activations as compared to HCF, RTC and RTX. CONCLUSIONS We conclude that small circular objects, in rotation, tend to leave greater hallucinating impressions in the visual region. The similarity between observed activation patterns and those reported in conditions such as epilepsy and visual hallucinations can help elucidate the cortical mechanisms underlying these conditions. Trial Registration 1121_GWJUNG.

中文翻译：

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功能性磁共振成像研究人类纹状体皮质中的幻觉。

目的人类经常经历恐惧，恐惧症，偏头痛和幻觉，然而，支撑这些状况的大脑机制仍知之甚少。为了实现这一目标，在这项工作中，我们旨在将人类的视觉感知与幻觉相关联，并将其映射到他们的大脑起源。方法进行了功能磁共振成像研究，以检查人脑枕叶中的视觉皮层区域，包括纹状体，寄生状和周质性皮层。招募了24名健康受试者，并使用了四种视觉模式，包括幻觉圆（HCC），幻觉扇（HCF），视网膜检影圆（RTC）和视网膜检影十字（RTX），以记录其在上述视觉相关区域的影响。使用单向方差分析来评估诱导激活之间差异的显着性。多项式回归和K均值用于对大脑视觉区域的激活模式进行聚类。结果由于刺激的表现，在视觉皮层中观察到了明显的激活。视觉刺激引起的反应被分解为Brodmann区域17、18和19。激活数据聚类为独立且互斥的簇，与HCF，RTC和RTX相比，HCC记录了更高的激活。结论我们得出的结论是，旋转的小圆形物体往往会在视觉区域留下较大的幻觉印象。观察到的激活模式与在诸如癫痫和视觉幻觉等条件下报道的激活模式之间的相似性可以帮助阐明这些条件下的皮层机制。试用注册号1121_GWJUNG。