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The role of C957T, TaqI and Ser311Cys polymorphisms of the DRD2 gene in schizophrenia: systematic review and meta-analysis.
Behavioral and Brain Functions ( IF 4.7 ) Pub Date : 2016-11-11 , DOI: 10.1186/s12993-016-0114-z Thelma Beatriz González-Castro 1 , Yazmín Hernández-Díaz 1 , Isela Esther Juárez-Rojop 2 , María Lilia López-Narváez 3 , Carlos Alfonso Tovilla-Zárate 4 , Alma Genis-Mendoza 5 , Mariela Alpuin-Reyes 2
Behavioral and Brain Functions ( IF 4.7 ) Pub Date : 2016-11-11 , DOI: 10.1186/s12993-016-0114-z Thelma Beatriz González-Castro 1 , Yazmín Hernández-Díaz 1 , Isela Esther Juárez-Rojop 2 , María Lilia López-Narváez 3 , Carlos Alfonso Tovilla-Zárate 4 , Alma Genis-Mendoza 5 , Mariela Alpuin-Reyes 2
Affiliation
BACKGROUND
The association between the dopamine D2 receptor (DRD2) gene and schizophrenia has been studied though no conclusive outcomes have been attained. The aim of this study was to perform a systematic review and meta-analysis to explore the relation between three polymorphisms of the DRD2 gene (C957T, TaqI and Ser311Cys) and schizophrenia.
METHODS
The search was made in PubMed and EBSCO databases (up to February 2016). The systematic review included 34 case-control association studies (34 for C957T, 16 for TaqI and 36 for Ser311Cys). The association analysis comprised the allelic, additive, dominant, and recessive genetic models. The meta-analysis was performed following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement.
RESULTS
The meta-analysis showed that TaqI (additive model: OR 0.57, 95% CI 0.30-1.14) and C957T (additive model: OR 0.75, 95% OR 0.58-0.97, recessive model: OR 0.79, 95% CI 0.64-0.98) exert a protective effect against developing schizophrenia. However, the sub-analysis for the C957T variant showed that this polymorphism exhibits a risk factor effect on Chinese individuals (allelic model: OR 1.33, 95% CI 1.04-1.70).
CONCLUSION
Our meta-analysis suggests an association of the DRD2 gene and the risk for schizophrenia, given that TaqI and C957T polymorphisms presented a protective effect against schizophrenia, and in the sub-analyses the C957T variant increased the risk for this disorder in the Chinese population.
更新日期：2019-11-01
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