Parenteral lipid emulsions, which are made of oils from plant and fish sources, contain different types of tocopherols and tocotrienols (vitamin E homologs). The amount and types of vitamin E homologs in various lipid emulsions vary considerably and are not completely known. The objective of this analysis was to develop a quantitative method to determine levels of all vitamin E homologs in various lipid emulsions. An HPLC system was used to measure vitamin E homologs using a Pinnacle DB Silica normal phase column and an isocratic, n-hexane:1,4 dioxane (98:2) mobile phase. An optimized protocol was used to report vitamin E homolog concentrations in soybean oil-based (Intralipid®, Ivelip®, Lipofundin® N, Liposyn® III, and Liposyn® II), medium- and long-chain fatty acid-based (Lipofundin®, MCT and Structolipid®), olive oil-based (ClinOleic®), and fish oil-based (Omegaven®) and mixture of these oils-based (SMOFlipid®, Lipidem®) commercial parenteral lipid emulsions. Total content of all vitamin E homologs varied greatly between different emulsions, ranging from 57.9 to 383.9 µg/mL. Tocopherols (α, β, γ, δ) were the predominant vitamin E homologs for all emulsions, with tocotrienol content < 0.3%. In all of the soybean emulsions, except for Lipofundin® N, the predominant vitamin E homolog was γ-tocopherol, which ranged from 57–156 µg/mL. ClinOleic® predominantly contained α-tocopherol (32 µg/mL), whereas α-tocopherol content in Omegaven® was higher than most of the other lipid emulsions (230 µg/mL). Practical applications The information on the types and quantity of vitamin E homologs in various lipid emulsions will be extremely useful to physicians and healthcare personnel in selecting appropriate lipid emulsions that are exclusively used in patients with inadequate gastrointestinal function, including hospitalized and critically ill patients. Some emulsions may require vitamin E supplementation in order to meet minimal human requirements.

中文翻译：

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肠外脂质乳剂中的生育酚和生育三烯酚同系物

由植物和鱼类来源的油制成的肠胃外脂质乳剂含有不同类型的生育酚和生育三烯酚（维生素 E 同系物）。各种脂质乳剂中维生素 E 同系物的数量和类型差异很大，目前尚不完全清楚。该分析的目的是开发一种定量方法来确定各种脂质乳液中所有维生素 E 同系物的水平。使用 HPLC 系统测量维生素 E 同系物，使用 Pinnacle DB Silica 正相柱和等度正己烷:1,4 二恶烷 (98:2) 流动相。使用优化的方案来报告基于大豆油（Intralipid®、Ivelip®、Lipofundin® N、Liposyn® III 和 Liposyn® II）、基于中链和长链脂肪酸（Lipofundin® , MCT 和 Structolipid®), 橄榄油基 (ClinOleic®), 和鱼油基 (Omegaven®) 和这些油基混合物 (SMOFlipid®, Lipidem®) 商业肠外脂质乳剂。所有维生素 E 同系物的总含量在不同乳液之间差异很大，范围从 57.9 到 383.9 µg/mL。生育酚（α、β、γ、δ）是所有乳液的主要维生素 E 同系物，生育三烯酚含量 < 0.3%。在所有大豆乳液中，除了 Lipofundin® N，主要的维生素 E 同系物是 γ-生育酚，范围为 57–156 µg/mL。ClinOleic® 主要含有 α-生育酚 (32 µg/mL)，而 Omegaven® 中的 α-生育酚含量高于大多数其他脂质乳剂 (230 µg/mL)。实际应用 各种脂质乳剂中维生素 E 同系物的类型和数量的信息对于医生和医护人员在选择专门用于胃肠功能不全的患者（包括住院和危重病患者）的适当脂质乳剂时非常有用。一些乳液可能需要补充维生素 E 才能满足最低限度的人体需求。