Parvovirus B19 (B19V) and human bocavirus 1 (HBoV1), members of the large Parvoviridae family, are human pathogens responsible for a variety of diseases. For B19V in particular, host features determine disease manifestations. These viruses are prevalent worldwide and are culturable in vitro, and serological and molecular assays are available but require careful interpretation of results. Additional human parvoviruses, including HBoV2 to -4, human parvovirus 4 (PARV4), and human bufavirus (BuV) are also reviewed. The full spectrum of parvovirus disease in humans has yet to be established. Candidate recombinant B19V vaccines have been developed but may not be commercially feasible. We review relevant features of the molecular and cellular biology of these viruses, and the human immune response that they elicit, which have allowed a deep understanding of pathophysiology.

中文翻译：

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人类细小病毒。

细小病毒 B19 (B19V) 和人博卡病毒 1 (HBoV1) 属于细小病毒科大家族的成员，是导致多种疾病的人类病原体。特别是对于 B19V，宿主特征决定疾病表现。这些病毒在世界范围内流行，并且可以在体外培养，并且可以进行血清学和分子检测，但需要仔细解释结果。还回顾了其他人类细小病毒，包括 HBoV2 至 -4、人类细小病毒 4 (PARV4) 和人类蟾蜍病毒 (BuV)。人类细小病毒疾病的全谱尚未确定。候选重组 B19V 疫苗已经开发出来，但可能在商业上不可行。我们回顾了这些病毒的分子和细胞生物学的相关特征，以及它们引起的人类免疫反应，这使得我们能够深入了解病理生理学。