BACKGROUND Early diastolic left ventricular (LV) filling can be accurately described using the same methods used in classical mechanics to describe the motion of a loaded spring as it recoils, a validated method also referred to as the Parameterized Diastolic Filling (PDF) formalism. With this method, each E-wave recorded by pulsed wave (PW) Doppler can be mathematically described in terms of three constants: LV stiffness (k), viscoelasticity (c), and load (x 0). Also, additional parameters of physiological and diagnostic interest can be derived. An efficient software application for PDF analysis has not been available. We aim to describe the structure, feasibility, time efficiency and intra-and interobserver variability for use of such a solution, implemented in Echo E-waves, a freely available software application ( www.echoewaves.org ). RESULTS An application was developed, with the ability to open DICOM files from different vendors, as well as rapid semi-automatic analysis and export of results. E-waves from 20 patients were analyzed by two investigators. Analysis time for a median of 34 (interquartile range (IQR) 29-42) E-waves per patient (representing 63 %, IQR 56-79 % of the recorded E-waves per patient) was 4.3 min (IQR 4.0-4.6 min). Intra-and intraobserver variability was good or excellent for 12 out of 14 parameters (coefficient of variation 2.5-18.7 %, intraclass correlation coefficient 0.80-0.99). CONCLUSION Kinematic analysis of diastolic function using the PDF method for Doppler echocardiography implemented in freely available semiautomatic software is highly feasible, time efficient, and has good to excellent intra-and interobserver variability.

中文翻译：

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使用免费软件Echo E-waves进行舒张功能的运动学分析-可行性和可重复性。

背景技术早期舒张期左心室（LV）充盈可以使用经典力学中用来描述加载弹簧回弹的运动的相同方法来准确描述，这是一种经过验证的方法，也称为参数化舒张充盈（PDF）形式。使用此方法，可以用三个常数在数学上描述由脉冲多普勒（PW）多普勒记录的每个E波：LV刚度（k），粘弹性（c）和载荷（x 0）。而且，可以导出生理和诊断关注的其他参数。尚未提供用于PDF分析的有效软件应用程序。我们旨在描述在Echo E-waves（可免费获得的软件应用程序，www.echoewaves.org）中实现的这种解决方案的结构，可行性，时间效率以及观察者内部和观察者之间的差异。结果开发了一个应用程序，它能够打开来自不同供应商的DICOM文件，以及快速的半自动分析和结果导出功能。两名研究人员分析了20名患者的电波。每位患者中位34条（四分位范围（IQR）29-42）E波的中值分析时间（代表每位患者记录的E波的63％，IQR 56-79％IQR）为4.3分钟（IQR 4.0-4.6分钟）。14个参数中的12个参数的观察者内和观察者内变异性良好或优异（变异系数2.5-18.7％，组内相关系数0.80-0.99）。结论在免费的半自动软件中使用PDF方法进行多普勒超声心动图的舒张功能运动学分析是高度可行，省时的，并且具有良好的观察者间和观察者间变异性。