BACKGROUND The aim of this study was to determine the value of 18F-FDG uptake on screening PET/CT images for the prediction of Helicobacter pylori (H. pylori) infection and chronic atrophic gastritis. METHODS Among subjects who underwent 18F-FDG PET/CT for cancer screening from April 2005 to November 2015, PET/CT images were analyzed in 88 subjects who had gastrointestinal fiberscopy within 6 months. The volumes of interest (VOIs) were placed in the fornix, corpus and antrum of the stomach to determine maximal standardized uptake value (SUVmax) and mean SUV (SUVmean). Receiver operating characteristic curve (ROC) analysis was performed to determine the diagnostic performance of SUV indicators in predicting H. pylori infection and chronic atrophic gastritis. RESULTS SUV indicators of the stomach were significantly higher in subjects with H. pylori infection than those without (from P < 0.001 to P < 0.05). ROC analysis revealed that SUVmean had the highest performance in predicting H. pylori infection (AUC 0.807) and chronic atrophic gastritis (AUC 0.784). SUVmean exhibited the sensitivity of 86.5 % and the specificity of 70.6 % in predicting H. pylori infection, and the sensitivity of 75.0 % and 78.6 % in predicting chronic atrophic gastritis. CONCLUSION Assessment of 18F-FDG uptake in the stomach reflecting active inflammation is useful in predicting patients with H. pylori infection and subsequent chronic atrophic gastritis which is closely associated with the risk of gastric neoplasms.

中文翻译：

---

筛查PET / CT时在胃中摄取18F-FDG：预测幽门螺杆菌感染和慢性萎缩性胃炎的价值。

背景技术这项研究的目的是确定18F-FDG摄取在筛选PET / CT图像中的价值，以预测幽门螺杆菌（H. pylori）感染和慢性萎缩性胃炎。方法从2005年4月至2015年11月对18F-FDG PET / CT进行癌症筛查的受试者中，对88例在6个月内进行了胃肠镜检查的受试者的PET / CT图像进行了分析。将感兴趣的体积（VOI）放置在胃的穹,、 corp体和胃窦中，以确定最大标准化摄取值（SUVmax）和平均SUV（SUVmean）。进行受试者工作特征曲线（ROC）分析，以确定SUV指标在预测幽门螺杆菌感染和慢性萎缩性胃炎中的诊断性能。结果患有H的受试者的胃SUV指标显着更高。幽门螺杆菌感染率高于无幽门螺杆菌感染者（P <0.001至P <0.05）。ROC分析显示，SUVmean在预测幽门螺杆菌感染（AUC 0.807）和慢性萎缩性胃炎（AUC 0.784）方面表现最高。SUVmean对幽门螺杆菌感染的预测灵敏度为86.5％，特异性为70.6％，对慢性萎缩性胃炎的预测灵敏度为75.0％和78.6％。结论评估反映活动性炎症的胃中18 F-FDG摄取有助于预测幽门螺杆菌感染和随后的慢性萎缩性胃炎患者，这与胃肿瘤的发生风险密切相关。807）和慢性萎缩性胃炎（AUC 0.784）。SUVmean对幽门螺杆菌感染的预测灵敏度为86.5％，特异性为70.6％，对慢性萎缩性胃炎的预测灵敏度为75.0％和78.6％。结论评估反映活动性炎症的胃中18 F-FDG摄取有助于预测幽门螺杆菌感染及随后的慢性萎缩性胃炎，这与胃肿瘤的发生风险密切相关。807）和慢性萎缩性胃炎（AUC 0.784）。SUVmean对幽门螺杆菌感染的预测灵敏度为86.5％，特异性为70.6％，对慢性萎缩性胃炎的预测灵敏度为75.0％和78.6％。结论评估反映活动性炎症的胃中18 F-FDG摄取有助于预测幽门螺杆菌感染及随后的慢性萎缩性胃炎，这与胃肿瘤的发生风险密切相关。