Patients with chronic schizophrenia-related disorders are at a heightened risk of developing cardiovascular disease. The presence and interpretation of cerebral vascular lesions in neuroimaging tests in these patients represents a common clinical challenge. Nevertheless, the literature on cerebrovascular disease in this population is scarce and contradictory. The aim of this study was to analyse the relationship between schizophrenia-related disorders and cerebrovascular morbidity. A case-control study compared cerebrovascular morbidity in a group of patients with schizophrenia-related disorder versus a group of patients with another severe mental illness. The risk of presenting cerebrovascular morbidity was four times higher and statistically significant in patients with schizophrenia-related disorders compared with controls, paired by age and sex. However, both groups were homogeneous in terms of cardiovascular risk factors. There were significant differences between the two groups only in the time using first-generation antipsychotic drugs and taking two or more antipsychotic medications simultaneously. The relationship between chronic schizophrenia-related disorders and cerebrovascular disease may be beyond the classic cardiovascular risk factors and related to certain medications. This is one of the first studies to focus on the relation among cerebrovascular morbidity, antipsychotic drugs and disorders related to schizophrenia in middle-aged and elderly adults.

中文翻译：

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在患有慢性精神分裂症相关疾病的患者中，脑血管疾病是否是一种沉默疾病？

患有慢性精神分裂症相关疾病的患者罹患心血管疾病的风险更高。这些患者在神经影像学检查中脑血管病变的存在和解释代表了常见的临床挑战。然而，关于这一人群中脑血管疾病的文献很少且相互矛盾。这项研究的目的是分析精神分裂症相关疾病与脑血管发病率之间的关系。一项病例对照研究比较了一组精神分裂症相关疾病患者与另一组严重精神疾病患者的脑血管发病率。与精神分裂症相关疾病的患者相比，精神分裂症相关疾病患者出现脑血管疾病的风险高四倍，且在统计学上具有统计学意义，按年龄和性别配对。但是，就心血管危险因素而言，两组均是同质的。两组之间只有在使用第一代抗精神病药并同时服用两种或多种抗精神病药时才存在显着差异。慢性精神分裂症相关疾病与脑血管疾病之间的关系可能超出了经典的心血管危险因素，并且与某些药物有关。这是针对中老年人的脑血管发病率，抗精神病药和精神分裂症相关疾病之间关系的首批研究之一。两组之间只有在使用第一代抗精神病药并同时服用两种或多种抗精神病药时才存在显着差异。慢性精神分裂症相关疾病与脑血管疾病之间的关系可能超出了经典的心血管危险因素，并且与某些药物有关。这是针对中老年人的脑血管发病率，抗精神病药物和精神分裂症相关疾病之间关系的首批研究之一。两组之间只有在使用第一代抗精神病药并同时服用两种或多种抗精神病药时才存在显着差异。慢性精神分裂症相关疾病与脑血管疾病之间的关系可能超出了经典的心血管危险因素，并且与某些药物有关。这是针对中老年人的脑血管发病率，抗精神病药物和精神分裂症相关疾病之间关系的首批研究之一。