Reduction in hippocampal volume is a hallmark of schizophrenia and already present in the clinical high-risk state. Nevertheless, other subcortical structures, such as the thalamus, amygdala and pallidum can differentiate schizophrenia patients from controls. We studied the role of hippocampal and subcortical structures in clinical high-risk individuals from two cohorts. High-resolution T1-weighted structural MRI brain scans of a total of 91 clinical high-risk individuals and 64 healthy controls were collected in two centers. The bilateral volume of the hippocampus, the thalamus, the caudate, the putamen, the pallidum, the amygdala, and the accumbens were automatically segmented using FSL-FIRST. A linear mixed-effects model and a prospective meta-analysis were applied to assess group-related volumetric differences. We report reduced hippocampal and thalamic volumes in clinical high-risk individuals compared to healthy controls. No volumetric alterations were detected for the caudate, the putamen, the pallidum, the amygdala, or the accumbens. Moreover, we found comparable medium effect sizes for group-related comparison of the thalamus in the two analytical methods. These findings underline the relevance of specific alterations in the hippocampal and subcortical volumes in the high-risk state. Further analyses may allow hippocampal and thalamic volumes to be used as biomarkers to predict psychosis.

中文翻译：

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精神病高危人群的海马和丘脑改变。

海马体积的减少是精神分裂症的标志，并且已经处于临床高危状态。然而，其他皮质下结构，例如丘脑，杏仁核和苍白球可将精神分裂症患者与对照区分开。我们研究了来自两个队列的临床高风险个体中海马和皮层下结构的作用。在两个中心收集了91位临床高风险个体和64位健康对照的高分辨率T1加权结构MRI脑扫描。使用FSL-FIRST自动分割海马，丘脑，尾状，壳核，苍白球，杏仁核和伏隔的双侧体积。应用线性混合效应模型和前瞻性荟萃分析来评估与组相关的体积差异。我们报告与健康对照组相比，临床高危人群海马和丘脑体积减少。未检测到尾状，壳状，苍白质，杏仁核或伏隔肌的体积变化。此外，我们在两种分析方法中发现了与丘脑的组相关比较可比较的中等效应大小。这些发现强调了在高风险状态下海马和皮层下体积的特定变化的相关性。进一步的分析可以将海马和丘脑的体积用作预测精神病的生物标志物。我们在两种分析方法中发现了与丘脑的组相关比较具有可比的中等效应大小。这些发现强调了在高风险状态下海马和皮层下体积的特定变化的相关性。进一步的分析可以将海马和丘脑的体积用作预测精神病的生物标志物。我们在两种分析方法中发现了与丘脑的组相关比较具有可比的中等效应大小。这些发现强调了在高风险状态下海马和皮层下体积的特定变化的相关性。进一步的分析可以将海马和丘脑的体积用作预测精神病的生物标志物。