Genome instability is a hallmark of both cancer and aging processes. Beyond cell-autonomous responses, it is known that DNA damage also elicits systemic mechanisms aimed at favoring survival and damaged cells clearance. Among these mechanisms, immune activation and NF-κB-mediated inflammation play central roles in organismal control of DNA damage. We focus herein on the different experimental evidences that have allowed gaining mechanistic insight about this relationship. We also describe the functional consequences of defective immune function in cancer development and age-related alterations. Finally, we discuss different intervention strategies based on enhancing immunity or on the modulation of the inflammatory response to improve organism homeostasis in cancer and aging.

中文翻译：

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对癌症和衰老中DNA损伤的免疫和炎症反应。

基因组不稳定性是癌症和衰老过程的标志。除了细胞自主反应以外，已知DNA损伤还引发了旨在促进存活和受损细胞清除的系统机制。在这些机制中，免疫激活和NF-κB介导的炎症在DNA损伤的机体控制中起着核心作用。在此，我们将重点放在允许获得有关此关系的机械洞察力的不同实验证据上。我们还描述了癌症发展和与年龄相关的变化中免疫功能缺陷的功能后果。最后，我们讨论了基于增强免疫力或调节炎症反应以改善癌症和衰老中生物体内稳态的不同干预策略。