The issue of drug chirality is attracting increasing attention among the scientific community. The phenomenon of chirality has been overlooked in environmental research (environmental occurrence, fate and toxicity) despite the great impact that chiral pharmacologically active compounds (cPACs) can provoke on ecosystems. The aim of this paper is to introduce the topic of chirality and its implications in environmental contamination. Special attention has been paid to the most recent advances in chiral analysis based on liquid chromatography coupled with mass spectrometry and the most popular protein based chiral stationary phases. Several groups of cPACs of environmental relevance, such as illicit drugs, human and veterinary medicines were discussed. The increase in the number of papers published in the area of chiral environmental analysis indicates that researchers are actively pursuing new opportunities to provide better understanding of environmental impacts resulting from the enantiomerism of cPACs.

中文翻译：

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手性液相色谱与串联质谱联用对环境中手性药理活性化合物的对映体分析

药物手性问题正引起科学界越来越多的关注。尽管手性药理活性化合物 (cPAC) 可以对生态系统产生巨大影响，但在环境研究（环境发生、归宿和毒性）中，手性现象一直被忽视。本文的目的是介绍手性的主题及其在环境污染中的影响。特别关注基于液相色谱与质谱联用的手性分析的最新进展以及最流行的基于蛋白质的手性固定相。讨论了几组与环境相关的 cPAC，例如非法药物、人类和兽药。