The Notch signaling pathway is a reiteratively used cell to cell communication pathway that triggers pleiotropic effects. The correct regulation of the pathway permits the efficient regulation of genes involved in cell fate decision throughout development. This activity relies notably on the CSL proteins, (an acronym for CBF-1/RBPJ-κ in Homo sapiens/Mus musculus respectively, Suppressor of Hairless in Drosophila melanogaster, Lag-1 in Caenorhabditis elegans) which is the unique transcription factor and DNA binding protein involved in this pathway. The CSL proteins have the capacity to recruit activation or repression complexes according to the cellular context. The aim of this review is to describe the different co-repressor proteins that interact directly with CSL proteins to form repression complexes thereby regulating the Notch signaling pathway in animal cells to give insights into the paralogous evolution of these co-repressors in higher eumetazoans and their subsequent effects at developmental processes.

中文翻译：

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CSL蛋白，多功能转录因子和Notch信号通路的上下文相关核心表达因子。

Notch信号传导途径是触发多效效应的可重复使用的细胞间通讯途径。途径的正确调节允许在整个发育过程中有效调节参与细胞命运决定的基因。该活性特别依赖于CSL蛋白（独特的转录因子和DNA）（Como蛋白/小家鼠分别为CBF-1 /RBPJ-κ，黑腹果蝇的无毛抑制物，秀丽隐杆线虫的Lag-1）。参与该途径的结合蛋白。CSL蛋白具有根据细胞环境募集激活或阻遏复合物的能力。