Nuclear architecture and the chromatin state affect most-if not all- DNA-dependent transactions, including the ability of cells to sense DNA lesions and restore damaged DNA back to its native form. Recent evidence points to functional links between DNA damage sensors, DNA repair mechanisms and the innate immune responses. The latter raises the question of how such seemingly disparate processes operate within the intrinsically complex nuclear landscape and the chromatin environment. Here, we discuss how DNA damage-induced immune responses operate within chromatin and the distinct sub-nuclear compartments highlighting their relevance to chronic inflammation.

中文翻译：

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DNA损伤引起的炎症和核结构。

核结构和染色质状态会影响大多数（如果不是全部）依赖DNA的交易，包括细胞感知DNA损伤并将受损的DNA恢复为天然形式的能力。最近的证据表明，DNA损伤传感器，DNA修复机制与先天免疫反应之间存在功能联系。后者提出了一个问题，即这种看似完全不同的过程在本质上复杂的核景观和染色质环境中如何运作。在这里，我们讨论了DNA损伤诱导的免疫反应如何在染色质和不同的亚核区室中发挥作用，突出了它们与慢性炎症的相关性。