Understanding of the synthesis kinetics and our ability to modulate medium conditions allowed us to generate nanoparticles via an ultra-fast process. The synthesis medium is kept quite simple with tetraethyl orthosilicate (TEOS) as precursor and 50% ethanol and sodium hydroxide catalyst. Synthesis is performed under gentle conditions at 20 °C for 20 min Long synthesis time and catalyst-associated drawbacks are most crucial in silica nanoparticle synthesis. We have addressed both these bottlenecks by replacing the conventional Stober catalyst, ammonium hydroxide, with sodium hydroxide. We have reduced the overall synthesis time from 20 to 1/3 h, ~60-fold decrease, and obtained highly monodispersed nanoparticles with 5-fold higher surface area than Stober particles. We have demonstrated that the developed NPs with ~3-fold higher silane can be used as efficient probes for biosensor applications.

中文翻译：

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氢氧化钠催化的单分散高表面积二氧化硅纳米粒子。


对合成动力学的了解以及我们调节介质条件的能力使我们能够通过超快的过程生成纳米颗粒。合成介质非常简单，以原硅酸四乙酯 (TEOS) 作为前体，使用 50% 乙醇和氢氧化钠催化剂。合成在 20 °C 的温和条件下进行 20 分钟 合成时间长和催化剂相关的缺点是二氧化硅纳米颗粒合成中最重要的。我们通过用氢氧化钠取代传统的斯托伯催化剂氢氧化铵来解决这两个瓶颈。我们将总合成时间从 20 小时缩短至 1/3 小时，减少约 60 倍，并获得比 Stober 颗粒表面积高 5 倍的高度单分散纳米颗粒。我们已经证明，所开发的纳米粒子的硅烷含量高出约 3 倍，可用作生物传感器应用的有效探针。