An association between drug treatment for viral infections and severe cutaneous adverse reactions has been noted. We investigated six patients diagnosed with Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) after being prescribed acetaminophen for suspected viral illnesses. Multiplex analysis was performed to measure cytokine levels in sera before and after treatment. IL-2Rα levels significantly decreased during the convalescence phase. Although acetaminophen is relatively safe, the drug can trigger SJS/TEN in patients with suspected viral infections. T-cells and monocytes may be key components of the link between viral infection and acetaminophen-induced SJS/TEN.

中文翻译：

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病毒感染期间使用对乙酰氨基酚相关的 Stevens-Johnson 综合征和中毒性表皮坏死松解症

已经注意到病毒感染的药物治疗与严重的皮肤不良反应之间存在关联。我们调查了 6 名因疑似病毒性疾病被开具对乙酰氨基酚处方后诊断为史蒂文斯-约翰逊综合征 (SJS) 和中毒性表皮坏死松解症 (TEN) 的患者。进行多重分析以测量治疗前后血清中的细胞因子水平。IL-2Rα 水平在恢复期显着降低。尽管对乙酰氨基酚相对安全，但该药可在疑似病毒感染的患者中引发 SJS/TEN。T 细胞和单核细胞可能是病毒感染和对乙酰氨基酚诱导的 SJS/TEN 之间联系的关键组成部分。