Production of high affinity antibodies for antigens is a critical component for the immune system to fight off infectious pathogens. However, it could be detrimental to our body when the antigens that B cells recognize are of self-origin. Follicular helper T, or Tfh, cells are required for the generation of germinal center reactions, where high affinity antibody-producing B cells and memory B cells predominantly develop. As such, Tfh cells are considered as targets to prevent B cells from producing high affinity antibodies against self-antigens, when high affinity autoantibodies are responsible for immunopathologies in autoimmune disorders. This review article provides an overview of current understanding of Tfh cells and discusses it in the context of animal models of autoimmune diseases and allograft rejections for generation of novel therapeutic interventions.

中文翻译：

---

自身免疫性疾病和同种异体移植排斥中的滤泡辅助 T (Tfh) 细胞

产生针对抗原的高亲和力抗体是免疫系统抵抗传染性病原体的关键组成部分。然而，当 B 细胞识别的抗原是自身来源的时，它可能对我们的身体有害。生发中心反应的产生需要滤泡辅助 T 细胞或 Tfh 细胞，其中产生高亲和力抗体的 B 细胞和记忆 B 细胞主要发育。因此，当高亲和力自身抗体导致自身免疫性疾病的免疫病理学时，Tfh 细胞被认为是防止 B 细胞产生针对自身抗原的高亲和力抗体的靶点。