Allergic inflammation requires the orchestration of altered gene expression in the target tissue and in the infiltrating immune cells. The transcription factor STAT6 is critical in activating cytokine gene expression and cytokine signaling both in the immune cells and in target tissue cells including airway epithelia, keratinocytes and esophageal epithelial cells. STAT6 is activated by the cytokines IL-4 and IL-13 to mediate the pathogenesis of allergic disorders such as asthma, atopic dermatitis, food allergy and eosinophilic esophagitis (EoE). In this review, we summarize the role of STAT6 in allergic diseases, its interaction with the co-factor PARP14 and the molecular mechanisms by which STAT6 and PARP14 regulate gene transcription.

中文翻译：

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STAT6 和 PARP 家族成员在 T 细胞依赖性过敏性炎症发展中的作用

过敏性炎症需要在靶组织和浸润免疫细胞中协调改变的基因表达。转录因子 STAT6 在激活免疫细胞和靶组织细胞（包括气道上皮细胞、角质形成细胞和食管上皮细胞）中的细胞因子基因表达和细胞因子信号传导方面至关重要。STAT6 被细胞因子 IL-4 和 IL-13 激活以介导过敏性疾病的发病机制，例如哮喘、特应性皮炎、食物过敏和嗜酸性粒细胞性食管炎 (EoE)。在这篇综述中，我们总结了 STAT6 在过敏性疾病中的作用、它与辅因子 PARP14 的相互作用以及 STAT6 和 PARP14 调节基因转录的分子机制。