A primary characteristic of autism, which is a neurodevelopmental disorder, is impaired social interaction and communication. Furthermore, patients with autism frequently show abnormal social recognition. In mouse models of autism, social recognition is usually assessed by examining same-sex social behavior using various tests, such as the three-chamber test. However, no studies have examined the ability of male mice with autism to recognize the estrous cycle of female partners. In this study, we investigated the sexual behaviors, especially mounting and ultrasonic vocal communication (USV), of BTBR T+ tf/J (BTBR) mice, which are used as a well-known mouse model of autism, when they encountered estrus or diestrus female mice. As expected, C57BL/6 mice mounted more female mice in the estrus stage compared with the diestrus stage. We found that BTBR mice also mounted more female mice in the estrus stage than female mice in the diestrus stage. Although the USV emission of male mice was not different between estrus and diestrus female mice in both strains, the mounting result implies that BTBR mice distinguish sexual receptivity of females.

中文翻译：

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女性发情周期对雄性C57BL / 6和自闭症BTBR T + tf / J小鼠性行为和超声波发声的影响。

自闭症的主要特征是神经发育障碍，它是社交互动和交流障碍的原因。此外，自闭症患者经常表现出异常的社会认可度。在自闭症小鼠模型中，通常通过使用各种测试（例如三室测试）检查同性的社交行为来评估社交认可度。但是，尚无研究检查自闭症雄性小鼠识别雌性伴侣发情周期的能力。在这项研究中，我们调查了BTBR T + tf / J（BTBR）小鼠的性行为，尤其是坐骑和超声波声通信（USV），当它们遇到发情期或发情期时，它们被用作自闭症的著名小鼠模型雌鼠。如预期的那样，与发情期相比，C57BL / 6小鼠在发情期安装了更多的雌性小鼠。我们发现，BTBR小鼠在发情期的雌性小鼠也比发情期的雌性小鼠多。尽管在这两种品系中，雄性小鼠的USV发射在发情期和雌性雌性小鼠之间没有差异，但安装结果表明BTBR小鼠可以区分雌性。