Alzheimer's disease (AD) is the most common form of dementia among older persons. Thymoquinone (TQ) has anti-inflammatory, anticonvulsant and antioxidant activity. A novel α7 nicotinic acetyl choline receptor (α7 nAChR ) agonist (PNU- 282987) have been identified to enhance the cognitive performance. An alternative treatment strategy via compounds known as nicotinic "positive allosteric modulators" (PAMs) has been reported. This study was designed to investigate the combination of PAM of α7 nAChRs with PNU- 282987 or with TQ as a possible treatment for AD in rat.

中文翻译：

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胸腺醌、α7 受体激动剂和 α7 受体变构调节剂对实验性阿尔茨海默病中与 MSCs 活化相关的大脑皮层的影响。

阿尔茨海默病 (AD) 是老年人中最常见的痴呆症。百里醌（TQ）具有抗炎、抗惊厥和抗氧化活性。已鉴定出一种新型α 7 烟碱型乙酰胆碱受体 ( α 7 nAChR) 激动剂 (PNU-282987) 可增强认知能力。已经报道了一种通过称为烟碱“正变构调节剂”(PAM) 的化合物的替代治疗策略。本研究旨在研究α 7 nAChR 的 PAM 与 PNU-282987 或与 TQ 的组合作为大鼠 AD 的可能治疗方法。