Objectives

Our goal is to develop a double lumen cannula (DLC) for a percutaneous right ventricular assist device (pRVAD) in order to eliminate two open chest surgeries for RVAD installation and removal. The objective of this study was to evaluate the performance, flow pattern, blood hemolysis, and thrombosis potential of the pRVAD DLC.

Methods

Computational fluid dynamics (CFD), using the finite volume method, was performed on the pRVAD DLC. For Reynolds numbers <4000, the laminar model was used to describe the blood flow behavior, while shear-stress transport k–ω model was used for Reynolds numbers >4000. Bench testing with a 27 Fr prototype was performed to validate the CFD calculations.

Results

There was <1.3% difference between the CFD and experimental pressure drop results. The Lagrangian approach revealed a low index of hemolysis (0.012% in drainage lumen and 0.0073% in infusion lumen) at 5 l/min flow rate. Blood stagnancy and recirculation regions were found in the CFD analysis, indicating a potential risk for thrombosis.

Conclusions

The pRVAD DLC can handle up to 5 l/min flow with limited potential hemolysis. Further modification of the pRVAD DLC is needed to address blood stagnancy and recirculation.

中文翻译：

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右心室辅助装置系统的经皮双腔插管：计算流体动力学研究。

目标

我们的目标是开发一种用于经皮右心室辅助设备（pRVAD）的双腔插管（DLC），以消除用于RVAD安装和拆卸的两次开胸手术。这项研究的目的是评估pRVAD DLC的性能，血流模式，血液溶血和血栓形成潜力。

方法

使用有限体积法对pRVAD DLC进行了计算流体动力学（CFD）。对于雷诺数> 4000的雷诺数，使用层流模型来描述血流行为，而对于雷诺数> 4000的剪切力传递k - ω模型进行描述。使用27 Fr原型进行了基准测试，以验证CFD计算。

结果

CFD和实验压降结果之间的差异<1.3％。拉格朗日方法显示流速为5 l / min时溶血指数较低（引流管腔内为0.012％，输注管腔内为0.0073％）。在CFD分析中发现血液停滞和回流区域，表明存在血栓形成的潜在风险。

结论

pRVAD DLC可以以有限的潜在溶血速度处理高达5 l / min的流量。需要对pRVAD DLC进行进一步修改，以解决血液停滞和再循环问题。