Backround:Possible toxic effects of hyperoxia have been reported previously. However, the number of studies investigating the influence of hyperoxia on blood cells is limited and there are no data regarding its hemorheological effects. OBJECTIVE The aim of this study was to investigate the effects of acute hyperoxia, performed in human subjects at normal atmospheric pressure, on the rheological properties of blood. METHOD The study was conducted with 12 brain death patients mechanically ventilated in the intensive care unit. The patients were ventilated with 21%, 40%, and 100% oxygen before induction of apnea testing performed for diagnosis of brain death. Blood samples were obtained at each oxygen concentration value for all patients. RESULT The results of the study indicated no significant change of red blood cell aggregation, deformability and plasma or whole blood viscosity associated with acute hyperoxia at normobaric conditions. CONCLUSION The results of the study suggest that application of normobaric hyperoxia does not have detrimental effects on hemorheological parameters in brain death patients, and that organs considered for donation from such subjects are not adversely affected by abnormalities of blood flow and tissue perfusion.

中文翻译：

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急性和短期常压高氧对血液流变学参数的影响。

背景：先前已经报道了高氧血症的可能的毒性作用。然而，研究高氧对血细胞影响的研究数量是有限的，并且没有关于其血液流变学效应的数据。目的本研究的目的是研究在正常大气压下在人类受试者中进行的急性高氧血症对血液流变特性的影响。方法本研究是对12名在重症监护室进行机械通气的脑死亡患者进行的。在进行呼吸暂停测试以诊断脑死亡之前，先给患者通风21％，40％和100％的氧气。在所有患者的每个氧气浓度值下获得血样。结果研究结果表明红细胞聚集没有明显变化，在常压条件下与急性高氧有关的可变形性和血浆或全血粘度。结论研究结果表明，常压高氧的使用对脑死亡患者的血液流变学参数没有不利影响，并且考虑从这些对象捐赠的器官不会受到血流和组织灌注异常的不利影响。