Engineered cardiac tissues hold great promise for use in drug and toxicology screening, in vitro studies of human physiology and disease, and as transplantable tissue grafts for myocardial repair. In this review, we discuss recent progress in cell-based therapy and functional tissue engineering using pluripotent stem cell-derived cardiomyocytes and we describe methods for delivery of cells into the injured heart. While significant hurdles remain, notable advances have been made in the methods to derive large numbers of pure human cardiomyocytes, mature their phenotype, and produce and implant functional cardiac tissues, bringing the field a step closer to widespread in vitro and in vivo applications.

中文翻译：

---

人类心脏组织工程：从多能干细胞到心脏修复。


工程心脏组织在药物和毒理学筛选、人体生理学和疾病的体外研究以及作为心肌修复的可移植组织移植物方面具有广阔的应用前景。在这篇综述中，我们讨论了使用多能干细胞衍生的心肌细胞进行基于细胞的治疗和功能组织工程的最新进展，并描述了将细胞输送到受伤心脏的方法。尽管仍然存在重大障碍，但在获取大量纯人类心肌细胞、使其表型成熟以及产生和植入功能性心脏组织的方法方面已经取得了显着进展，使该领域距离广泛的体外和体内应用又近了一步。