The tetracyclines (TTC) and sulfonamides are among the most common residues found in bulk raw milk samples. Detection of drug residues in bulk milk (BM) tankers demonstrates that the product is not suitable for human consumption. Discarding BM with residue-contaminated milk is a waste of a valuable commodity, and a repurposing for consumption at calf ranches is a way to recapture some value. However, if calves consuming milk with drug residues are slaughtered for veal, their meat could contain drug residues. The objective of this review is to provide a residue avoidance strategy for TTC and sulfonamide residues in veal. To determine the pharmacokinetic properties of each drug a structured review of the literature was performed and the study inclusion criteria were that the publication used dairy breed calves, with body weight <330 kg or <6 months of age. The most pertinent parameters were determined to be plasma, tissue elimination half-lives, and systemic bioavailability. The results of this review were integrated with milk and tissue testing levels of quantification and tissue tolerances to formulate a recommended withdrawal interval for calves ingesting this milk. The suggested withdrawal interval of 20 days will ensure that no veal calves will test positive for residues from being fed this milk.

中文翻译：

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确认阳性散装原料奶罐车转移到小牛牧场的协议——四环素和磺胺类药物在小牛中的药代动力学综述

四环素 (TTC) 和磺胺类药物是散装原料奶样品中最常见的残留物。散装牛奶 (BM) 罐车中的药物残留检测表明该产品不适合人类食用。将 BM 与受残留污染的牛奶一起丢弃是对宝贵商品的浪费，而将其重新用于小牛牧场消费是重新获得一些价值的一种方式。但是，如果将食用含有药物残留牛奶的小牛屠宰为小牛肉，则它们的肉可能含有药物残留。本综述的目的是为小牛肉中的 TTC 和磺胺类残留物提供一种避免残留物的策略。为了确定每种药物的药代动力学特性，对文献进行了结构化审查，研究纳入标准是该出版物使用了体重<330 kg或< 6个月大。最相关的参数被确定为血浆、组织消除半衰期和全身生物利用度。该审查的结果与牛奶和组织测试的量化水平和组织耐受性相结合，以制定建议的犊牛摄入这种牛奶的停药间隔。建议的 20 天停药间隔将确保小牛犊不会因喂食这种牛奶而检测出残留物呈阳性。