Chemokines and their corresponding receptors serve as pro-inflammatory and migratory signals for immune cells. CXCR3 and its corresponding ligands, CXCL9, CXCL10 and CXCL11, participate in the induction of immune responses against several foreign antigens. Numerous cells, including macrophages, NK cells and T lymphocytes, express CXCR3 and thus, expression of the receptor and its ligands can induce activity of these important immune cells against foreign antigens, including allogeneic grafts. Several parameters of the immune system participate in the induction and stimulation of powerful immune responses against allogeneic grafts. A thorough understanding of the parameters that regulate these responses can provide insights into new methods for immunotherapy during organ transplantation. The aim of this review is to address the most recent information regarding the roles played by CXCR3 and its corresponding ligands in the outcome of renal transplantation.

中文翻译：

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CXCR3及其配体在肾移植预后中的作用。

趋化因子及其相应的受体可作为免疫细胞的促炎和迁移信号。CXCR3及其相应的配体CXCL9，CXCL10和CXCL11参与了针对几种外源抗原的免疫应答的诱导。包括巨噬细胞，NK细胞和T淋巴细胞在内的众多细胞表达CXCR3，因此，受体及其配体的表达可以诱导这些重要的免疫细胞针对异源抗原（包括同种异体移植物）的活性。免疫系统的几个参数参与了针对同种异体移植物的强大免疫反应的诱导和刺激。对调节这些反应的参数的透彻了解可以为器官移植过程中免疫疗法的新方法提供深刻见解。