BACKGROUND Devices gauging viscoelastic properties of blood during coagulation like the thromboelastograph support fundamental research as well as point of care needs. Associated fibrinolysis data are based on endogenous species or plasminogen activator added to a homogeneous sample prior to clot formation. Digestion in a monolithic structure differs from the physical situation of thrombolytic therapy where surface reactions dominate. OBJECTIVE This study aims to develop rheological testing for heterogeneous phase fibrinolysis. METHOD Fibrinolysis rates were determined by phase change of a solid clot induced by autologous plasma/streptokinase (SK) in a rheometer sensitive to viscous damping. RESULTS Initial slope or overall change in the logarithmic damping factor indicated fibrinolytic rates. Rates depended on clot geometry, phase volumes, clot composition and SK concentration. CONCLUSION The damped oscillation rheometer can be adapted to determine relative rates of heterogeneous fibrinolysis in vitro.

中文翻译：

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阻尼振荡流变法测定非均相纤维蛋白溶解速率。

背景技术诸如血栓弹性描记仪之类的在凝结期间测量血液的粘弹性的装置支持基础研究以及护理需求。相关的纤维蛋白溶解数据是基于血凝块形成之前添加到均质样品中的内源性物种或纤溶酶原激活剂。整体结构中的消化与溶栓治疗的物理情况不同，在溶栓治疗中，表面反应占主导地位。目的本研究旨在为异相纤维蛋白溶解发展流变学测试。方法通过在对粘性阻尼敏感的流变仪中，由自体血浆/链激酶（SK）诱导的固体凝块的相变来确定纤溶速率。结果初始斜率或对数阻尼因子的整体变化表明纤维蛋白溶解率。速率取决于血块的几何形状，相体积，血块组成和SK浓度。结论阻尼振荡流变仪可适用于确定体外异纤蛋白溶解的相对速率。