Invadosomes are actin rich protrusive structures that facilitate invasive migration in multiple cell types. Comprised of invadopodia and podosomes, these highly dynamic structures adhere to and degrade the extracellular matrix, and are also thought to play a role in mechanosensing. Many extracellular signals have been implicated in invadosome stimulation, activating complex signalling cascades to drive the formation, activity and turnover of invadosomes. While the structural components of invadosomes have been well studied, the regulation of invadosome dynamics is still poorly understood. Protein kinases are essential to this regulation, affecting all stages of invadosome dynamics and allowing tight spatiotemporal control of their activity. Invadosome organisation and function have been linked to pathophysiological states such as cancer invasion and metastasis; therapeutic targeting of invadosome regulatory components is thus warranted. In this review, we discuss the involvement of kinase signalling in every stage of the invadosome life cycle and evaluate its significance.

中文翻译：

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动态侵袭体中激酶活性的意义。

Invadosomes 是富含肌动蛋白的突出结构，可促进多种细胞类型的侵入性迁移。这些高度动态的结构由入侵伪足和足体组成，粘附并降解细胞外基质，并且还被认为在机械传感中发挥作用。许多细胞外信号与侵入体刺激有关，激活复杂的信号级联以驱动侵入体的形成、活动和周转。虽然侵入体的结构成分已经得到很好的研究，但对侵入体动力学的调节仍然知之甚少。蛋白激酶对于这种调节是必不可少的，它影响着侵入体动力学的所有阶段，并允许对其活动进行严格的时空控制。侵袭体的组织和功能与癌症的侵袭和转移等病理生理状态有关；因此，有必要对侵入体调节成分进行治疗靶向。在这篇综述中，我们讨论了激酶信号在侵袭体生命周期的每个阶段的参与，并评估了其重要性。