Human mesenchymal stem cells (hMSCs) are attractive candidates for cell therapy and regenerative medicine due to their multipotency and ready availability, but their application can be complicated by the factors such as age of the donors and senescence-associated growth arrest during culture conditions. The latter most likely reflects the fact that aging of hMSCs is associated with a rise in intracellular reactive oxygen species, loss of telomerase activity, decrease in human telomerase reverse transcriptase (hTERT) expression and finally eroded telomere ends. Over-expression of telomerase in hMSCs leads to telomere elongation and may help to maintain replicative life-span of these cells. The aim of this study was to evaluate of the effect of L-carnitine (LC) as an antioxidant on the telomerase gene expression and telomere length in aged adipose tissue-derived hMSCs.

中文翻译：

---

左旋肉碱有效诱导人脂肪组织间充质干细胞的hTERT基因表达从老年受试者获得。

人间充质干细胞（hMSCs）具有多能性和易于使用的特点，因此是细胞疗法和再生医学的诱人候选物，但由于诸如捐赠者的年龄以及培养条件下衰老相关的生长停滞等因素，其应用可能变得复杂。后者最可能反映出以下事实：hMSC的衰老与细胞内活性氧的增加，端粒酶活性的丧失，人端粒酶逆转录酶（hTERT）表达的降低以及端粒末端最终被侵蚀有关。hMSCs中端粒酶的过度表达导致端粒延长，并可能有助于维持这些细胞的复制寿命。