Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets different substrates for ubiquitylation and therefore regulates a variety of cellular processes such as cell division, differentiation, genome stability, energy metabolism, cell death, autophagy as well as carcinogenesis. Activity of APC/C is principally governed by two WD-40 domain proteins, Cdc20 and Cdh1, in and beyond cell cycle. In the past decade, the results based on numerous biochemical, 3D structural, mouse genetic and small molecule inhibitor studies have largely attracted our attention into the emerging role of APC/C and its regulation in biological function, human diseases and potential therapeutics. This review will aim to summarize some recently reported insights into APC/C in regulating cellular function, connection of its dysfunction with human diseases and its implication of therapeutics.

中文翻译：

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深入了解APC / C：从细胞功能到疾病和治疗方法。

后期促进复合物/环体（APC / C）是一种多功能泛素蛋白连接酶，可针对不同的底物进行泛素化，因此可调节多种细胞过程，例如细胞分裂，分化，基因组稳定性，能量代谢，细胞死亡，自噬等。以及致癌作用。在细胞周期内外，APC / C的活性主要受两个WD-40域蛋白Cdc20和Cdh1支配。在过去的十年中，基于众多生化，3D结构，小鼠遗传和小分子抑制剂研究的结果在很大程度上引起了我们对APC / C及其在生物学功能，人类疾病和潜在疗法中的调节作用的关注。这篇综述旨在总结最近报道的有关APC / C在调节细胞功能中的一些见解，