Beta-lactam antibiotics serve as a cornerstone in the management of bacterial infections because of their wide spectrum of activity and low toxicity. Since resistance rates among bacteria are continuously on the rise and the pipeline for new antibiotics does not meet this trend, an optimization of current beta-lactam treatment is needed. This review provides an overview of optimization through use of prolonged- and continuous-infusion dosing strategies compared with more traditional intermittent infusions. Included is an overview of the scientific basis for using these nontraditional prolonged- and continuous-infusion-based regimens, with a focus on major areas in which the clinical laboratory can support the clinical use of these regimens.

中文翻译：

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连续和延长静脉内β-内酰胺剂量：对临床实验室的意义。

β-内酰胺类抗生素具有广谱的活性和低毒性，因此成为细菌感染管理的基石。由于细菌之间的耐药率不断上升，并且新抗生素的生产线不符合这一趋势，因此需要对当前的β-内酰胺治疗进行优化。与传统的间歇性输注相比，本综述提供了通过使用长期和连续输注剂量策略进行优化的概述。其中概述了使用这些非传统的基于长期和持续输注的方案的科学基础，重点是临床实验室可以支持这些方案临床使用的主要领域。