Surgical adhesive biomaterials have emerged as substitutes to sutures and staples in many clinical applications. Nano-enabled materials containing nanoparticles or having a distinct nanotopography have been utilized for generation of a new class of surgical materials with enhanced functionality. In this review, the state of the art in the development of conventional surgical adhesive biomaterials is critically reviewed and their shortcomings are outlined. Recent advancements in generation of nano-enabled surgical materials with their potential future applications are discussed. This review will open new avenues for the innovative development of the next generation of tissue adhesives, hemostats, and sealants with enhanced functionality for various surgical applications.

中文翻译：

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手术材料：当前挑战和纳米解决方案

在许多临床应用中，外科粘合生物材料已成为缝线和U形钉的替代品。含有纳米颗粒或具有独特纳米形貌的纳米材料已被用于生成具有增强功能的新型外科材料。在这篇综述中，对传统手术粘合生物材料的开发最新技术进行了严格的回顾，并概述了它们的缺点。讨论了纳米外科材料的最新进展及其潜在的未来应用。此次审查将为下一代组织粘合剂、止血剂和密封剂的创新开发开辟新途径，这些组织粘合剂、止血剂和密封剂具有增强的功能，适用于各种手术应用。