Implantable intracortical microelectrodes face an uphill struggle for widespread clinical use. Their potential for treating a wide range of traumatic and degenerative neural disease is hampered by their unreliability in chronic settings. A major factor in this decline in chronic performance is a reactive response of brain tissue, which aims to isolate the implanted device from the rest of the healthy tissue. In this review we present a discussion of materials approaches aimed at modulating the reactive tissue response through mechanical and biochemical means. Benefits and challenges associated with these approaches are analyzed, and the importance of multimodal solutions tested in emerging animal models are presented.

中文翻译：

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通过机械和生化手段调节神经组织对植入微电极反应的材料方法。


植入式皮质内微电极在临床广泛应用方面面临着艰巨的挑战。它们治疗各种创伤性和退行性神经疾病的潜力因其在慢性环境中的不可靠性而受到阻碍。慢性性能下降的一个主要因素是脑组织的反应性反应，其目的是将植入的设备与其他健康组织隔离。在这篇综述中，我们讨论了旨在通过机械和生化手段调节反应性组织反应的材料方法。分析了与这些方法相关的好处和挑战，并介绍了在新兴动物模型中测试的多模式解决方案的重要性。