Correct selection of an appropriate animal mode to closely mimic human extremity diseases or to exhibit desirable phenotypes of limb regeneration is the first critical step for all scientists in biomedical and regenerative researches. The commonly-used animals in limb regeneration and repairing studies, such as axolotl, mice, and rats, are discussed in the review and other models including cockroaches, dogs, and horses are also mentioned. The review weighs the general advantages, disadvantages, and precedent uses of each model in the context of limb and peripheral injury and subsequent regeneration. We hope that this review can provide the reader an overview of each model, from which to select one for their specific purpose.

正确选择合适的动物模式以紧密模仿人类肢体疾病或展现理想的肢体再生表型，是所有从事生物医学和再生医学研究的科学家的第一步。该综述讨论了肢体再生和修复研究中常用的动物，例如x，小鼠和大鼠，还提到了其他模型，包括蟑螂，狗和马。审查权衡了每种模型在肢体和周围损伤以及随后的再生中的一般优势，劣势和先例使用。我们希望这篇评论可以为读者提供每种模型的概述，并从中为特定目的选择一种模型。