Excessive angiogenesis (i.e., the formation of new blood vessels) contributes to different pathologies, among them cancer and ocular disorders. Conversely, dysfunction of endothelial cells (ECs) contributes to cardiovascular complications, as is the case in diabetes. Inhibition of pathologic angiogenesis in blinding eye disease and cancer by targeting growth factors such as vascular endothelial growth factor has become an accepted therapeutic strategy. However, recent studies also unveiled the emerging importance of EC metabolism in controlling angiogenesis. In this overview, we will discuss recent insights in the metabolic regulation of angiogenesis, focusing on the best-characterized metabolic pathways, and highlight deregulation of EC metabolism in cancer and diabetes. We will give an outlook on how targeting EC metabolism can be used for blocking pathologic angiogenesis and for normalizing EC dysfunction.

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通过靶向内皮代谢来操纵血管生成：是发动引擎而非驱动器的新视角？

过度的血管生成（即新血管的形成）导致了不同的病理，其中包括癌症和眼部疾病。相反，内皮细胞（EC）的功能障碍会导致心血管并发症，就像糖尿病一样。通过靶向诸如血管内皮生长因子的生长因子来抑制致盲眼疾病和癌症中的病理性血管生成已成为公认的治疗策略。但是，最近的研究也揭示了EC代谢在控制血管生成中的重要性。在本概述中，我们将讨论在血管生成代谢调节方面的最新见解，重点是最典型的代谢途径，并着重指出在癌症和糖尿病中EC代谢的失调。