The HIV genome encodes a small number of viral proteins (i.e., 16), invariably establishing cooperative associations among HIV proteins and between HIV and host proteins, to invade host cells and hijack their internal machineries. As a known example, the HIV envelope glycoprotein GP120 is closely associated with GP41 for viral entry. From a genome-wide perspective, a hypothesis can be worked out to determine whether 16 HIV proteins could develop 120 possible pairwise associations either by physical interactions or by functional associations mediated via HIV or host molecules. Here, we present the first systematic review of experimental evidence on HIV genome-wide protein associations using a large body of publications accumulated over the past 3 decades. Of 120 possible pairwise associations between 16 HIV proteins, at least 34 physical interactions and 17 functional associations have been identified. To achieve efficient viral replication and infection, HIV protein associations play essential roles (e.g., cleavage, inhibition, and activation) during the HIV life cycle. In either a dispensable or an indispensable manner, each HIV protein collaborates with another viral protein to accomplish specific activities that precisely take place at the proper stages of the HIV life cycle. In addition, HIV genome-wide protein associations have an impact on anti-HIV inhibitors due to the extensive cross talk between drug-inhibited proteins and other HIV proteins. Overall, this study presents for the first time a comprehensive overview of HIV genome-wide protein associations, highlighting meticulous collaborations between all viral proteins during the HIV life cycle.

中文翻译：

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HIV基因组全蛋白协会：30年研究回顾。

HIV基因组编码少量的病毒蛋白（即16种），始终在HIV蛋白之间以及HIV与宿主蛋白之间建立协作联系，从而侵入宿主细胞并劫持它们的内部机制。作为已知的例子，HIV包膜糖蛋白GP120与GP41紧密结合以用于病毒进入。从全基因组的角度来看，可以得出一个假设，以确定16种HIV蛋白是否可以通过物理相互作用或通过HIV或宿主分子介导的功能性结合而发展出120种可能的成对关联。在这里，我们使用过去3年中积累的大量出版物，对HIV基因全蛋白关联的实验证据进行了首次系统的综述。在16种HIV蛋白质之间的120种可能的成对关联中，至少已经确定了34种物理相互作用和17种功能关联。为了实现有效的病毒复制和感染，HIV蛋白协会在HIV生命周期中起着至关重要的作用（例如，裂解，抑制和激活）。每个HIV蛋白都以一种必不可少的或必不可少的方式与另一种病毒蛋白协同作用，以完成恰好在HIV生命周期的适当阶段发生的特定活动。此外，由于药物抑制蛋白与其他HIV蛋白之间的广泛串扰，HIV基因组蛋白的整体关联对抗HIV抑制剂也有影响。总的来说，这项研究首次全面介绍了艾滋病毒全基因组蛋白的关联，强调了在艾滋病生命周期中所有病毒蛋白之间的精心合作。