The impact of DNA damage-induced immune responses on aging and disease development is a topic of growing scientific interest and debate. While abundant data links persistent genotoxic stress and associated inflammatory activity to organ decline and cancer development, evidence of pro-homeostatic nature of immune responses triggered by transient DNA damage gradually accumulates. Current review focuses on comparing systemic outcomes of transient genotoxicity with effects of persistent DNA damage from the angle of associated immune activity. We discuss genotoxic stress as a potential damage associated molecular pattern (DAMP) which alerts the organism of the upcoming systemic dysfunction and pre-conditions the body for damage tolerance and repair.

中文翻译：

---

保护性和不良炎症反应中的DNA损伤：敌人的朋友？

DNA损伤诱导的免疫反应对衰老和疾病发展的影响是越来越多的科学兴趣和辩论的话题。尽管大量数据将持续的遗传毒性压力和相关的炎症活性与器官衰弱和癌症发展联系起来，但暂时性DNA损伤触发的免疫反应的促体内平衡性质逐渐得到了证明。当前的综述集中在从相关的免疫活性的角度比较暂时性基因毒性的系统性结果与持续性DNA损伤的影响。我们将遗传毒性应激作为潜在的损伤相关分子模式（DAMP）进行讨论，该模式可提醒机体即将出现的系统功能障碍，并为身体的损伤耐受性和修复提供前提条件。